Treatment Comparison

NeoGen vs RF Microneedling

Which Skin Rejuvenation Treatment Is Better for Your Skin?

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Tanya Cook-Riley, RN Licensed Esthetician, Founder
August 6, 2026 7 min read

When patients begin exploring non-surgical skin rejuvenation treatments, two procedures frequently come up in consultations. NeoGen plasma skin regeneration and RF microneedling. Both are designed to stimulate collagen production and improve the overall quality of the skin, but they use very different technologies to achieve these results.

Patients researching these procedures usually want answers to the same handful of questions. Is RF microneedling worth it? Is NeoGen better than RF microneedling? Which treatment works best for wrinkles, texture, or loose skin?

Understanding how each treatment works can help you make an informed decision based on your skin concerns, goals, and tolerance for downtime. Patients from Loomis, Roseville, Granite Bay, Rocklin, and Lincoln come to my studio for NeoGen plasma skin regeneration when they want natural skin rejuvenation without surgery.

What Is RF Microneedling?

RF microneedling is a treatment that combines traditional microneedling with radiofrequency energy to stimulate collagen production.

How RF Microneedling Works

During the treatment, a device with small sterile needles creates tiny micro channels in the skin. As the needles penetrate the skin, radiofrequency energy is delivered into the dermis, creating controlled thermal injury. This process stimulates the skin's natural healing response and encourages new collagen and elastin production.

Common RF microneedling devices include technologies like Morpheus8, Secret RF, and Vivace.

Skin Concerns RF Microneedling May Improve

  • Mild skin laxity
  • Fine lines and wrinkles
  • Acne scars
  • Enlarged pores
  • Mild texture irregularities
  • Early signs of aging

Because the treatment uses needles, some redness and swelling are expected following the procedure.

What Is NeoGen Plasma Skin Regeneration?

NeoGen plasma skin regeneration is a non-invasive skin treatment that uses nitrogen plasma energy to stimulate collagen remodeling and improve skin quality. Unlike RF microneedling, NeoGen does not use needles. Instead, it delivers controlled nitrogen plasma energy to the skin surface.

How NeoGen Works

Nitrogen gas is energized into plasma, which transfers heat to the skin in a controlled manner. This heat stimulates fibroblast activity in the dermis, encouraging collagen production and tissue remodeling. The treatment creates thermal stimulation without puncturing the skin, which can make it appealing if you prefer non-needle treatments. NeoGen can be customized with different energy levels to address varying degrees of skin aging.

Skin Concerns NeoGen May Address

  • Skin laxity
  • Deeper wrinkles
  • Crepey skin
  • Sun damage
  • Uneven skin texture
  • Acne scarring
  • Skin rejuvenation of the face, neck, and decolletage

Because plasma energy can penetrate deeper layers of the skin, NeoGen treatments are often chosen when patients want improvement in concerns such as skin laxity, deeper wrinkles, and uneven texture.

NeoGen vs RF Microneedling: Key Differences

While both procedures aim to rejuvenate the skin, the technology, depth of treatment, and potential results differ significantly.

1. Technology Used

NeoGen Plasma Regeneration

  • Uses nitrogen plasma energy
  • No needles involved
  • Delivers controlled thermal stimulation across the skin

RF Microneedling

  • Uses needles to penetrate the skin
  • Delivers radiofrequency heat into the dermis
  • Creates controlled micro injuries

Patients who prefer non-needle procedures often find NeoGen appealing.

2. Depth of Treatment

RF microneedling works primarily in the mid dermis, where collagen production occurs. NeoGen plasma energy can penetrate deeper layers of the skin, allowing for more significant tissue remodeling. Because of this, NeoGen may be considered when addressing moderate skin laxity and more advanced skin aging.

3. Skin Tightening Potential

Both treatments can stimulate collagen, but plasma energy may create more extensive dermal heating, which can help promote skin tightening. This is one reason NeoGen is sometimes selected when patients want noticeable rejuvenation without surgical procedures. Many patients combine regenerative technologies with the collagen-stimulating treatments on my microchanneling menu to achieve gradual, natural-looking improvements.

4. Treatment Areas

RF microneedling is commonly used on the face, neck, and acne scar areas. NeoGen plasma regeneration can treat the eyelids, decolletage, and hands. Its versatility allows me to address delicate areas such as the eyelids where some other treatments are limited.

5. Downtime and Recovery

NeoGen Recovery

  • Mild redness and warmth following treatment
  • Possible peeling depending on treatment settings
  • Gradual improvement over several weeks as collagen remodels

RF Microneedling Recovery

  • Redness for 1 to 3 days
  • Mild swelling possible
  • Minimal downtime for most patients

Downtime depends heavily on the treatment level selected.

Which Treatment Produces Better Results?

The answer depends largely on your skin concerns and treatment goals.

NeoGen May Be Better For

  • Advanced texture concerns
  • Deeper wrinkles and crepey skin
  • Moderate skin laxity
  • More significant collagen remodeling
  • Delicate areas like the eyelids

RF Microneedling May Be Ideal For

  • Patients seeking minimal downtime
  • Acne scarring
  • Fine lines and enlarged pores
  • Mild texture irregularities
  • Early signs of aging

In many cases, treatment plans can be customized or combined for optimal results.

The Role of Collagen Remodeling in Skin Rejuvenation

Collagen is the structural protein responsible for keeping skin firm, smooth, and youthful. Beginning in our mid twenties, collagen production gradually declines.

Worth Knowing

According to the American Academy of Dermatology, collagen loss contributes to wrinkles, sagging skin, and texture changes as we age.

Treatments like RF microneedling and plasma skin regeneration aim to stimulate the body's natural collagen production, which can improve skin structure over time.

1 to 3 Days of redness typically expected after RF microneedling
3 RF microneedling sessions in a typical series
24 Months that NeoGen results can continue improving

The PlasmaFecta™ Approach to Regenerative Skincare

At Good Skin Aesthetics in Loomis, I can also perform NeoGen treatments as part of the PlasmaFecta™ protocol, a three-phase regenerative treatment plan designed to support healthier skin. The protocol includes three stages:

  1. Prime. Skin is prepared with treatments that enhance cellular function and ready the tissue for collagen stimulation.
  2. Transform. NeoGen plasma energy stimulates collagen remodeling and rejuvenates skin structure.
  3. Maintain. Maintenance treatments preserve results and support ongoing skin health.

This regenerative approach focuses on improving skin biology rather than simply masking aging signs.

Who Is a Good Candidate for NeoGen or RF Microneedling?

The best treatment depends on individual skin concerns, age, and desired results. You may be a good candidate if you:

  • Want non-surgical skin rejuvenation
  • Have mild to moderate wrinkles
  • Are experiencing skin laxity
  • Want improvement in skin texture or scarring
  • Prefer treatments that stimulate natural collagen

A professional skin consultation can determine which treatment is most appropriate for your skin type and goals. Current options and investment levels are on my pricing page.

Choosing the Right Skin Rejuvenation Treatment

Both NeoGen plasma skin regeneration and RF microneedling are powerful tools for improving skin quality and stimulating collagen production.

The key difference lies in how the treatments deliver energy to the skin, and how deeply they can stimulate tissue remodeling.

RF microneedling can be a good option for early skin concerns and acne scarring, while NeoGen plasma regeneration may provide more significant rejuvenation for patients with deeper wrinkles, laxity, or advanced texture concerns. A professional consultation is the best way to determine which treatment aligns with your goals.

Frequently Asked Questions About NeoGen and RF Microneedling

NeoGen may produce stronger collagen remodeling because plasma energy can penetrate deeper layers of the skin. However, RF microneedling can still be effective for mild skin concerns.

RF microneedling can be beneficial for improving acne scars, fine lines, and early signs of aging. Results typically appear gradually as collagen production increases.

Results can continue improving for several months, up to 24 months, as collagen remodeling occurs. Maintenance treatments may help prolong results.

Most patients describe the treatment as warm or mildly uncomfortable. Topical numbing can be used to improve comfort.

Many patients undergo a series of three treatments spaced several weeks apart for optimal results.

NeoGen can stimulate collagen and may improve mild to moderate skin laxity.

Downtime varies depending on the treatment intensity. Some patients experience redness or peeling for several days.

Both RF microneedling and NeoGen may improve acne scarring by stimulating collagen remodeling.

Both treatments rely on the body's natural healing process and collagen production rather than synthetic fillers.

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Written By Tanya Cook-Riley, RN Licensed Esthetician, Founder

I am a Registered Nurse and Licensed Esthetician with over 15 years in medical aesthetics, dermatology, and plastic surgery. I see one client at a time in a private studio in Loomis, and every plan starts with education first.

Let Me Tell You Which One Your Skin Needs

Book a consultation and I will look at your texture, laxity, and downtime tolerance, then give you a straight answer.

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